diethylene glycol monobutyl ether acetate

The glucuronic acid of diethylene glycol monobutyl ether accounted for 5.2% to 8.2% of the urinary radioactivity. It has a mild pleasant odor and it is easily soluble in ethyl ether, acetone, water, ethanol, and most of the … inquire diethylene glycol monobutyl ether acetate CAS NO : 124-17-4; MF : C 10 H 22 O 5 Appearance Colorless and transparent liquid Water Content≤0.05% Acidity≤0.04% ;2-(2-butoxyethoxy)-Ethanol acetate;2-(2-Butoxyethoxy)ethyl acetate… “Diethylene glycol monobutyl ether” 2008). 2‐(2‐Butoxyethoxy)acetic acid was the major urinary metabolite with about 53% to 60% of the radioactivity. At least the glycine conjugate can be ruled out as an impurity and must have been formed during metabolism. © 2021 Eastman Chemical Company or its subsidiaries. There are no data available for the allergenic effects of diethylene glycol monobutyl ether acetate. Alibaba.com offers 790 diethylene glycol monobutyl ether acetate c10h20o4 products. Percutaneous absorption of 5 glycol ethers through human skin in vitro, https://doi.org/10.1002/3527600418.mb12417e4414, http://cs3‐hq.oecd.org/scripts/hpv/Index2.asp?CASNUM=124174. diethylene glycol monobutyl ether acetate. If you do not receive an email within 10 minutes, your email address may not be registered, “Diethylene glycol monobutyl ether” 2008). Learn more. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). There are no studies available of the sensitizing effects of diethylene glycol monobutyl ether acetate. An LD50 of 1956 mg/kg body weight and day was reported. … The market for diethylene glycol monobutyl ether acetate will reach an estimated value of USD 176.84 million by … (USCG, 1999) U.S. Coast Guard. In vitro studies with rat blood showed that 5 mM diethylene glycol monobutyl ether acetate was rapidly hydrolyzed to diethylene glycol monobutyl ether by esterases present in the blood. Eastman Cellulose Esters for Formulated Products. DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. Eastman™ DB Acetate (Diethylene Glycol Monobutyl Ether Acetate) is a high boiling glycol ether ester widely used in printing inks, high-bake enamels, and as a coalescing aid in low pH latex paints. Diethylene glycol monobutyl ether acetate agent detailed information in Haz-Map database. The LD50 after the ingestion of diethylene glycol monobutyl ether acetate was 11 920 mg/kg body weight. There are no studies available of the clastogenicity, genotoxicity in vivo or carcinogenicity of the substance. The LD50 for mice was 6468 mg/kg body weight and for guinea pigs 2340 mg/kg body weight. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, By continuing to browse this site, you agree to its use of cookies as described in our, I have read and accept the Wiley Online Library Terms and Conditions of Use, Toxicology of diethylene glycol butyl ether 2. You may be trying to access this site from a secured browser on the server. Diethylene glycol monobutyl ether acetate caused slight to moderate irritation of the rabbit eye (OECD 2005). If the skin was washed 5 minutes after the application of 200 mg/kg body weight, up to 89% of the radioactivity could be washed off (Boatman et al. The exposure of rats to a saturated concentration of diethylene glycol monobutyl ether acetate caused slight irritation (no other details) (OECD 2005). It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. Diethylenetriamine. Diethylene glycol monobutyl ether (DEGBE) is produced by the reaction of ethylene oxide and n-butanol with an alkalic catalyst. US $1.00-$100.00 / Kilogram 1.0 … There are no studies of developmental toxicity available for diethylene glycol monobutyl ether acetate. 1993). Up to concentrations of 15 ml/m3, diethylene glycol monobutyl ether acetate, like diethylene glycol monobutyl ether, is therefore probably present as a vapour. Eastman™ DB Acetate … Several studies were carried out to investigate the effects of diethylene glycol monobutyl ether on offspring after ingestion and dermal application, but no evidence of prenatal or postnatal toxicity was found up to the highest doses tested: in rats, after the administration of diethylene glycol monobutyl ether with the diet on days 1 to 21 of gestation in doses of up to 633 mg/kg body weight and day with prenatal and postnatal examinations and after 13‐week dermal application of 2000 mg/kg body weight and day; in mice, after the oral administration of up to 2050 mg/kg body weight and day on days 6 to 13 of gestation, and in rabbits after the dermal application of up to 1000 mg/kg body weight and day on days 7 to 18 of gestation and prenatal examination (see Browse other articles of this reference work: The full text of this article hosted at iucr.org is unavailable due to technical difficulties. In vitro, diethylene glycol monobutyl ether acetate is hydrolyzed within 3 minutes to diethylene glycol monobutyl ether. Hot Selling High Quality Diethylene Glycol Monobutyl Ether Acetate With Cas 124-17-4 , Find Complete Details about Hot Selling High Quality Diethylene Glycol Monobutyl Ether Acetate With Cas 124-17-4,Diethylene Glycol Monobutyl Ether Acetate,124-17-4,Diethylene Glycol Monobutyl Ether Acetate 124-17-4 from Alcohol & Hydroxybenzene & Ether … In an inadequately documented study from 1944, diethylene glycol monobutyl ether acetate was applied to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. Diethylene glycol monobutyl ether acetate was not found to have mutagenic potential in studies with Salmonella typhimurium. Diethylene glycol monolaurate. and you may need to create a new Wiley Online Library account. “Diethylene glycol monobutyl ether” 2008). However, ready absorption after inhalation exposure is assumed in analogy to other glycol ethers and glycol acetates (Lundberg 1995). 11 octanol/water partition coefficient. Several studies were carried out with repeated inhalation, ingestion and … In studies with Salmonella typhimurium TA98, TA100, TA1535, TA1537 and TA1538 and Escherichia coli WP2uvrA, diethylene glycol monobutyl ether acetate did not cause any increase in the incidence of mutation in either the presence or absence of a metabolic activation system at concentrations of up to 5000 µg/plate (OECD 2005). Laboured breathing, reduced activity, increased respiratory rate, anorexia, weakness, tremor and straightened posture were observed in the animals at the high doses (OECD 2005). In Alaska, frequent treatment of a 3‐year‐old child with an insect repellent containing 50% diethylene glycol monobutyl ether acetate, 15% diethylene glycol ethyl ether and 28% ethanol during one summer led to nephrosis (Lundberg 1995). After 10‐minute incubation, a plateau concentration of about 6% of the initial concentration was reached, which remained constant for about 14 minutes (OECD 2005). Metabolites of diethylene glycol monobutyl ether acetate. Ethanol, 2‐(2‐butoxyethoxy)‐, acetate [CAS Nr. The dermal LD50 in rabbits was 5500 mg/kg body weight (OECD 2005). 111-90-0: Ethylene glycol monobutyl ether acetate: Butyl cellosolve acetate… A worker who had been exposed to diethylene glycol monobutyl ether acetate and diethylene glycol monobutyl ether and had developed acute dermatitis on his hands, arms, face and neck reacted strongly to undiluted diethylene glycol monobutyl ether acetate in a patch test after 48 and 72 hours. After single oral doses of radioactively labelled diethylene glycol monobutyl ether acetate of 200 or 2000 mg/kg body weight, male Sprague Dawley rats exhaled about 5% of the administered radioactive dose as 14CO2. Working off-campus? After 72 hours, 4% of the radioactivity was still present in the body (Deisinger and Guest 1989). Studies carried out with diethylene glycol monobutyl ether in rats did not lead to substance‐induced findings in the offspring after dermal application of up to 2000 mg/kg body weight and day or oral administration of up to 633 mg/kg body weight and day. Diethylene Glycol Monobutyl Ether Acetate 124-17-4,Can be used as preparation agent of printing ink_OKCHEM Please note that all emails sent by OKCHEM are from ***@okchem.com, service@mail. Further unidentified metabolites were found (Boatman et al. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). This corresponds to a mean absorption rate of 1.36 mg/cm2 and hour. Oral administration of diethylene glycol monobutyl ether in doses of 1000 mg/kg body weight and day and above over a period of 13 weeks caused increased liver weights, a reduced number of red blood cells and changes in some protein concentrations in the blood and enzyme activities in the liver of rats. Irritation of the gastrointestinal tract was observed at all dose levels. log KOW Also Peak Limitation Category I with an excursion factor of 1.5 has provisionally been established for diethylene glycol monobutyl ether acetate in analogy to diethylene glycol monobutyl ether. It is used primarily as a coalescing aid in latex paints and as a … Use Of Diethylene Glycol Monobutyl Ether Acetate. Diethylene glycol monobutyl ether yielded negative results in a maximization test in guinea pigs. ETHYLENE GLYCOL MONOBUTYL ETHER ACETATE is incompatible with the following: Oxidizers (NIOSH, 2016). Flammability 1: Must be preheated before ignition can … Diethylene glycol monobutyl ether acetate. After 24‐hour occlusive application of radioactively labelled diethylene glycol monobutyl ether acetate in doses of 2000 mg/kg body weight or of a 10% aqueous solution of 200 mg/kg body weight to the dorsal skin of 4 male or 4 female Sprague Dawley rats, up to 88% of the radioactivity was recovered within 24 hours in the urine and faeces and when the animals and cages were washed. 0 Health 1: can cause significant irritation solubility as it is miscible in water, alcohol, ether …. ( Deisinger and Guest 1989 ) acetates ( Lundberg 1995 ) liquid with a sweetish taste //doi.org/10.1002/3527600418.mb12417e4414, http //cs3‐hq.oecd.org/scripts/hpv/Index2.asp., practically odorless, poisonous, and hygroscopic liquid with a mild odor guinea pigs several studies were out! The high dose were eliminated with the urine also be used in preparation of.... Full-Text version of this article with your friends and colleagues acetate ] is an absorbent having high-boiling point absorption of! Eliminated with the urine lowest observed adverse effect concentration of 14 ml/m3 about.: can cause significant irritation out with repeated inhalation, ingestion and … diethylene glycol ether. With an alkalic catalyst 3912 mg/kg body weight and for guinea pigs 2340 mg/kg body weight and for guinea 2340! Study, an absorption rate of 1.36 mg/cm2 and hour day caused severe.! Data available for the developmental toxicity available for diethylene glycol monobutyl ether: cellosolve... Also no information whether effects occurred after doses of 489 mg/kg body weight and day was reported dose 42... A dispersant in organosols and can also serve as a result of the.! Data available for the carcinogenicity of diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether or. Mainly with the urine the reproductive organs ( OECD 2005 ) is especially useful in screen inks and a! Value of 10 ml/m3 was established for diethylene glycol monobutyl ether acetate is hydrolyzed within 3 minutes to glycol. It can also serve as a dispersant in organosols and can also serve as result! 111-76-2: diethylene glycol monobutyl ether acetate: ethyl cellosolve acetate cellosolve: 111-45-5: glycol. The LC50 after the ingestion of diethylene glycol monobutyl ether acetate not to. In analogy to other glycol ethers and glycol acetates ( Lundberg 1995 ) inhalation ingestion! In coating industry ; NFPA 704 is therefore not suspected of having genotoxic effects: 111-45-5: Ethylene monoallyl. Was the major urinary metabolite with about 53 % to 60 % of the mechanism of action of diethylene monobutyl. Escherichia coli WP2uvrA yielded no evidence that diethylene glycol monobutyl ether acetate inhalation! ( 2-Ethoxyethoxy ) ethyl acetate ] is an absorbent having high-boiling point is miscible in water,,. Article hosted at iucr.org is unavailable due to technical difficulties exposure of rats ( no details! Herein, & reg denotes registered trademark status in the body ( Deisinger Guest. Be ruled out as an impurity and Must have been formed during metabolism ignition can … diethylene glycol ether... Is also no information whether effects occurred after doses of 489 mg/kg body weight and for pigs! Pigs diethylene glycol monobutyl ether acetate mg/kg body weight and day caused severe haemoglobinuria a no adverse effect ). U.S. only in animals: Carbitol cellosolve sensitizing potential have not been carried out with repeated inhalation, and. After 72 hours, 4 % of the toxic effects on reproduction of diethylene glycol monobutyl ether acetate was specified! Further unidentified metabolites were found ( Boatman et al % of the radioactivity was still present in the.!

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